Informatics for Integrating Biology and the Bedside, or i2b2, is an NIH-funded National Center for Biomedical Computing based within Partners HealthCare. The i2b2 Center is developing a scalable informatics framework to enable clinical researchers to use existing clinical data for discovery research.

Clinical Informatics Research and Development (CIRD) is responsible for leading the development of clinical systems strategy for Partners HealthCare, conducting applied informatics research and development, and key design issues in Partners enterprise clinical systems.

Clinical and Quality Analysis (CQA) conducts research evaluating the impact of clinical information systems on patient safety, quality, and care delivery.

Comprised of five groups, Partners Research Computing is a key component of the hospitals' research mission.