Antibody Core (BWH) - Kuchroo
The Antibody Core Facility provides commonly used monoclonal antibodies to the BWH research community. The antibodies are available in convenient 500µg aliquots at a cost substantially lower than that of commercial vendors.

Bioinformatics Core (HPCGG) - Kohane
The HPCGG Bioinformatics Core recognizes that quantitative analytic methods are now central to the pursuit of biomedical research. The intersection of information science, biostatistics, biology and clinical medicine requires multidisciplinary collaborative efforts that the Bioinformatics Core is designed to nurture. Whether it is expression microarrays, proteomic experiments or populations-wide linkage studies, the Bioinformatics Core works with investigators across the Harvard Medical community including affiliated hospitals. Activities of the Bioinformatics Core range from the provision of services to fully-collaborative grant-funded investigations.

Biospecimen Core (BWH) - Bry
The Crimson Biospecimen Core prospectively collects discarded clinical materials matching investigator-defined criteria against available information on clinical samples, including ICD.9 codes and results of clinical laboratory testing. Studies using the core must either (1) have an IRB-approved protocol for discarded clinical materials and anonymized information or (2) a protocol to allow collection of discarded samples from patients consented for their study. Collected samples may be additionally processed, aliquotted, or tested per the menu of clinical laboratory tests available within the BWH Clinical Laboratories.

Biosample Services Facility (HPCGG) - Morgan
The Biosample Services Facility provides a broad spectrum of biosample processing, management, and banking services to investigators in the Harvard-Partners research community. Services are available to IRB approved studies in the HMS-Partners community and beyond. We accept whole blood from appropriately consented subjects for processing to DNA, lymphoblast cell lines, serum, and plasma. We offer cryogenic storage of the purified products as required, in addition to tracking of sample histories in a Laboratory Information Management System dedicated to the BSF facility operation.

Biostatistics Core - CCI (BWH) - Hurwitz
Biostatistics support is available to investigators in the Brigham and Women's research community for statistical consulting on issues such as study design and data analysis for manuscripts and grant applications. Resources are limited, so planning ahead is essential. The Biostatistics Consulting Service is part of the Biostatistics Core of the Center for Clinical Investigation.

Cell Culture and Microscopy Core (BWH) – Rheinwald
The Cell Culture and Microscopy Core provides well-characterized primary and experimentally immortalized human cell lines, custom culture services, and training and access to a conventional fluorescence microscope and digital camera.

Clinical Genetic Research Facility (MGH) - Gusella
The Clinical Genetic Research Facility (CGRF) offers clinical investigators a convenient, modern research-dedicated facility for outpatient studies involving genetics. Our outpatient exam rooms and phlebotomy rooms are fully equipped, and an experienced medical assistant is available to facilitate the visits.

Clinical Research Program (MGH) - Crowley
The Clinical Research Program (CRP) is the MGH’s infrastructure for clinical investigators. Through five units, it provides direct services to faculty and staff for all types of clinical research (translational, trials and outcomes). The CRP also develops innovative tools to anticipate and enable future research opportunities. The five units include an Education Unit , Clinical Research Support Office (CRSO) , Genetics and Genomics Unit , Disease Management and Outcomes Unit, and an Information Management Unit.

Clinical Trials Center – CCI (BWH) - Stone
The Clinical Trials Center is a convenient facility for outpatient clinical trials. Infusion interview, exam, and procedure rooms are available for research staff, along with a touchdown space with telephone, fax, and computer access. Experienced personnel are on hand to perform phlebotomy, blood, and specimen processing, ECGs, and handle specimen packaging, shipping, and storage.

Confocal Microscope Core (BWH) - Kedersha
The Confocal Microscope Core provides access and assistance provided in the use of confocal microscopy with additional capabilities in live-cell imaging and photobleaching studies.

Confocal Core (BWH) - Mizuno
The Laser Confocal Core is dedicated to ensuring a timely access to the Confocal microscope equipment.

Confocal Microscope Core - Neuroscience (MGH) - Bhide
The purpose of the Neuroscience Microscope Core is to offer laser confocal microscopy services.

DNA Sequencing Core (BWH) - Kwiatkowski
The DNA Sequencing Core provides highly accurate, high quality DNA sequencing service to the BWH community, and other users as desired. Our turn-around-time is 36 to 72 hrs.

DNA Sequencing Core (HPCGG) - Iartchouk
The Sequencing core is involved in developing and implementing high throughput methods for the mapping, sequencing and resequencing of genes and genomes. The core has the ability to prepare plasmid libraries from genomic DNA, large insert clones, or PCR products. Robotic tools are used to pick colonies, array them into microtiter plates, prepare DNA and sequence the DNA using dideoxy chain termination chemistry.

DNA Sequencing Core (MGH) - Belmonte
The DNA Sequencing Core offers sequencing service in a timely, economical, and reliable manner. Results are made available to you over the internet as text-only files and chromatogram files which contain the fluorescent dye peaks the sequencer uses to determine base calls.

DNA Synthesis Core (MGH) - Moeller
The DNA Synthesis Core offers multiple scale synthesis of DNA oligonucleotides, both modified and unmodified.

Drosophila Genetics Core (MGH) - Perkins
Sixty percent of disease related genes in humans have conserved counterparts in flies. Virtually all of the signaling pathways implicated in cancer, metabolic diseases, and congenital birth defects are conserved in flies. The MGH Drosophila Genetics Core allows researchers the opportunity to benefit directly from the vast resources and knowledge that Drosophila offers as a genetically amenable, rapidly growing and relatively inexpensive model system.  Drosophila offers an alternative approach to addressing questions that are difficult or impossible in higher organisms and humans.

Education Core - CCI (BWH) - Chang
The Center for Clinical Investigation (CCI), offers educational services designed to promote high quality clinical research at BWH for both investigators and study coordinators. A range of workshops is offered to help train new research coordinators in how to conduct clinical studies. In addition, CCI offers ongoing continuing education sessions for experienced study coordinators who want to increase their knowledge regarding good clinical practices and current methods for performing high-quality clinical trials.

Electrophysiology Core (MGH) - Cantiello
The goal of the Electrophysiology Core (EPC) resource is to provide the MGH scientific and medical communities with a facility to help generate electrophysiological information, including characterization of channel function in various cell models and preparations. The EPC also provides highly skilled personnel for consultation, and the training of fellows and laboratory personnel.

Flow Cytometry Core (BWH) - Liao
To provide high standard cell sorting and analysis services to the research community at the Brigham and Women’s Hospital and the Longwood Medical area.

Flow Cytometry Core (MGH) – Preffer
The cell sorting and analysis lab provides access to the most sophisticated flow cytometers presently available. The core is able to analyze and physically separate cells based upon feathers detectable with fluorescently labeled monoclonal antibodies.

Gene Modification Lab (HPCGG) - Kucherlapati
The Gene Modification Laboratory was established to integrate and launch new technologies for rapid generation of gene-modified constructs and mutant mice for supporting mouse and human genetics research programs in the Harvard / Partners community.

Genotyping Facility (HPCGG) - Kwiatkowski
The Harvard Partners Genotyping Facility, provides flexible, high quality, high throughput SNP Genotyping.

Human Genetics Consult Service – CCI (BWH) - Celedon
The Human Genetics Consult Service, is a collaborative effort between the Harvard-Partners Center for Genetics and Genomics (HPCGG) and the Brigham and Women's Center for Clinical Investigation (CCI). This program is designed to provide consultation to investigators regarding the incorporation of genetics and genomics in their research, including help in arranging collaborations and accessing available resources for genotyping, sequencing and genetic epidemiology.

Microscopy and Image Analysis Core (MGH) - Waeber
The Microscopy and Image Analysis Core offers state-of-the-art software/hardware tools to generate and analyze quantitatively images obtained by a variety of experimental methods.

Microscopy Core (MGH) - Brown
The Microscopy Core of the Program in Membrane Biology (PMB) is equipped and staffed to provide a wide range of services to investigators from MGH and the Boston area scientific community in the area of light and electron microscopy.

PET Core (MGH) - Brady
The PET Core Laboratory provides a full range of technical and professional services for the design and execution of programs using Positron Emission Tomography (PET).

Proteomics Core (HPCGG) - Sarracino
The Proteomics center provides researchers with protein biochemistry and mass spectrometry resources in support of research projects.

Radiation Safety (MGH) - Woodleigh
The Radiation Safety Core/Office promotes the safe and effective use of radioactive material and too advise on polices and procedures to ensure compliance with state and federal regulations

Research Coordinator Network – CCI (BWH) - Stone
The Research Coordinator Network is designed to provide BWH investigators with a source for reliable and experienced research coordinators for clinical investigation. Coordinators are on hand to work simultaneously on a variety of protocols throughout the hospital, on a part- or full-time basis.

Tissue Banking Core (BWH) - Richards
This Tissue and Blood Repository Core provides specimen acquisition, processing and storage services, and access to archived frozen tissue specimens to the BWH/MGH/DFCI research community.

Transgenic and Knockout Facility - CBRC (MGH) - Georgopoulos
The transgenic core provides services, which includes microinjection of oocytes and transplantation of embryos into foster recipients for the generation of transgenic mice. ES cell injections and blastocyst transplantation to generate knockout mice is also covered. The facility is also equipped for the cryopreservation of 8-cell mouse embryos. The transfection service provides the technology and expertise necessary for the preparation of recombinant ES clones and their subsequent injection into host blastocysts.

Transgenic Core Facility - (BWH) - Sharpe
Transgenic Core Facility provides services for generating transgenic and knockout mice. Established in 1992, the BWH Core Facility has been providing gene targeting and microinjection services using state-of-the-art facilities and equipment.

Tumor Imaging Metrics Core (MGH/BWH/DF) - Harris/Barrish/VanDen Abbeele
The Tumor Imaging Metrics Core (TIMC) provides standardized, consistent, and efficient radiological measurements to evaluate tumor response. The Core makes reliable, quantitative, longitudinal measurements (such as linear dimension, RECIST, volume, function, etc.) of lesions from serial MRI, CT, and PET scan images. The Tumor Metrics Core provides a service for managing these images, making measurements in a routine, reliable, and centralized way, and making results available to investigators efficiently.

Virology Core - CFAR (BWH) - Kuritzkes
The Virology Core provides Flow Cytometry and Real-Time PCR services through the use of the Becton Dickinson FACSCalibur Flow Cytometer and ABI PRISM 7000 Sequence Detection System. The core provides highly accurate, high quality DNA sequencing services with a turn-around-time of 36 to 72 hrs.

Viral Vector Core (MGH) - Esteves
The Vector Core offers viral vectors with custom-designed promoters and reporter genes and capacity for gene regulation.

Web Development Core (MGH) - Hyde
Design and development of web sites for research throughout the Partners Healthcare System and affiliated institutions. Digital photography, print production and graphic arts services available.