The mission of the Tumor Imaging Metrics Core (TIMC) is to provide reliable and consistent standardized tumor measurements of radiological images to evaluate treatment response for oncology clinical trials. As an independent core lab the TIMC provides objective anatomic and functional imaging measurements which enhances the efficiency and quality of clinical trials using this service. Reliable tracking of lesion size and/or function is essential in clinical trials that use radiological measurements as surrogate endpoints.
| Personnel/Contact
Information: |
Co-Director (BWH): Matthew Barish, M.D.
Phone: (617) 732-6505
Fax: (617) 975-0946
Email: mbarish1@partners.org
Co-Director (MGH): Gordon Harris, Ph.D.
Phone: (617) 726-9464
Fax: (617) 724-6130
Email: gjharris@partners.org
Co-Director (DFCI): Annick Van den Abbeele, M.D.
Phone: (617) 632-2595
Fax: (617) 632-3581
Email: aabbeele@partners.org
Other Staff:
Core Manager: Bill Hanlon
Phone: (617) 643-0295
Fax: (617) 724-6130
Email: whanlon@partners.org
| Facilities
and Equipment: |
Locations of Cores:
Brigham and Women's Hospital, 3D and Image Processing
Center
Massachusetts General Hospital, 3D Imaging Service
Dana-Farber Cancer Institute, Department of Radiology, Division of Nuclear
Medicine
Major Equipment:
Imaging network connecting five DF/HCC imaging centers
2D and 3D image analysis workstations
Image study archive (PACS)
The Tumor Metrics Core provides four primary services
to DF/HCC investigators:
- Consultation
services for image-based protocol and image analysis design
- Image
aggregation and management of scans from all DF/HCC institutions
- Image
measurement of lesions from scans of patients on clinical trials
- Results
reporting and database management of radiological data for clinical
trials
The Tumor Imaging Metrics Core will maintain a database
of longitudinal radiological and
clinical data that will link to the Quality Assurance for Clinical Trials (QACT)
Core to provide
an auditable record of quantitative measurements for clinical trials conducted
through the
DF/HCC.
TIMC service fees (per scan) -- New rates apply to 09-xxx trials, effective 13-June-2008
| TIMC Service |
DF/HCC
Member |
Non-DF/HCC
Member |
Industry-Sponsored |
| RECIST (1) ch/ab/pel (CT/MR) |
$100 |
$200 |
$300 |
| WHO (2), IWRC (3), neuro, ch/ab/pel (CT/MR) |
$100 |
$200 |
$300 |
| Cheson (4) (NHL) neck/ch/ab/pel (CT/MR) |
$125 |
$250 |
$375 |
| SUV (5) neuro, maximum of five lesions (PET) |
$125 |
$250 |
$375 |
| SUV whole body, maximum of five lesions (PET) |
$125 |
$250 |
$375 |
| Choi (6) (CT w/contrast) |
$150 |
$300 |
$450 |
| NCI-96 (CT/MR) |
$150 |
$300 |
$450 |
| 3D Volume (7) - neuro, maximum of five lesions (MR) |
$150 |
$300 |
$450 |
(1) RECIST - Response Evaluation Criteria for Solid Tumors
(linear).
(2) WHO - World Health Organization criteria (bi-directional).
(3) IWRC - International Workshop Response Criteria (bi-directional).
(4) Cheson (sum of products of perpendicular diameters). An additional charge
of one scan
time-point will be applied if measurements must be repeated from baseline;
i.e. if new target
lesions are identified for a subject in accordance with Cheson response criteria
guidelines.
(5) SUV - Standard Uptake Value, using body weight formula.
(6) Choi - RECIST plus density measurements on CT scans w/contrast.
(7) Includes modified RECIST measurements for brain.
To access the core, please contact Bill Hanlon at (617)
643-0295 or by email at
whanlon@partners.org. Core services can also be requested by selecting
TIMC services
on the DFCI IRB New Project Request Form.
http://www.dfhcc.harvard.edu/core-facilities/tumor-imaging-metrics/
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