The HPCGG Bioinformatics Core recognizes that quantitative analytic methods are now
central to the pursuit of biomedical research. The intersection of information science,
biostatistics, biology and clinical medicine requires multidisciplinary collaborative efforts
that the Bioinformatics Core is designed to nurture. Whether it is expression microarrays,
proteomic experiments or populations-wide linkage studies, the Bioinformatics Core works
with investigators across the Harvard Medical community including affiliated hospitals.
Activities of the Bioinformatics Core range from the provision of services to fully-collaborative
grant-funded investigations.

Director: Isaac Kohane, M.D., Ph.D.
Phone: (617) 919-2184
Fax: (617) 730-0921
Email: isaac_kohane@harvard.edu

Associate Director: Marco Ramoni, Ph.D.
Phone: (617) 919-2185
Email: marco_ramoni@harvard.edu

Associate Director: Peter Park, Ph.D.
Phone: (617) 525-4468
Email: ppark@partners.org

Location of Core:

The facilities are located at 65 Landsdowne Street, Cambridge and 77 Avenue Louis Pasteur, NRB, Boston.

Major Equipment:

Agilent 2100 bioanalyzer
Affymetrix GeneChip® System
Model 320 hybridization oven
Model 450 Fluidics station
Model 3000 Scanner with autoloader

PIs using HPCGG Microarray services for the first time must have an initial project consultation (at no charge) before sending any samples to the Microarray Service. The scope of this consultation is limited to discussion about your experimental goals and the experimental designs necessary to provide the analysis. We will also discuss the resolving power of microarrays, types of microarrays available, the scope of analysis to expect, and the number of replicates and controls that are likely to be needed for assuring the best chance of achieving an useful analysis. At the time of this consultation we will review with you any analysis exceeding the basic comparative analysis and annotated gene listing provided with our services and based on the project's scope we will develop costs for the type analysis your are requesting.

More extensive grant development and collaboration support is also available. Our involvement here is designed to lead to submissions for grant funded research, co authorship on publications and or the grant itself. Support written into the grant is expected for funding of one Bioinformatics FTE, 10-20% funding for a Bioinformatics PI, and a postdoctoral student.

To access the core, please contact Isaac Kohane by email at isaac_kohane@harvard.edu. Please also see website at http://www.hpcgg.org.

http://www.hpcgg.org